3nd2 | pdb_00003nd2

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Template:STRUCTURE 3nd2

Structure of Yeast Importin-beta (Kap95p)

Template:ABSTRACT PUBMED 20826343

Function

[IMB1_YEAST] Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B.[1]

About this Structure

3nd2 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  1. Forwood JK, Lange A, Zachariae U, Marfori M, Preast C, Grubmuller H, Stewart M, Corbett AH, Kobe B. Quantitative structural analysis of importin-beta flexibility: paradigm for solenoid protein structures. Structure. 2010 Sep 8;18(9):1171-83. PMID:20826343 doi:10.1016/j.str.2010.06.015
  1. ↑ Mosammaparast N, Jackson KR, Guo Y, Brame CJ, Shabanowitz J, Hunt DF, Pemberton LF. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins. J Cell Biol. 2001 Apr 16;153(2):251-62. PMID:11309407

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