3oxo | pdb_00003oxo
From Proteopedia
Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA
Template:ABSTRACT PUBMED 20977214
Function
[SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
About this Structure
3oxo is a 8 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
- Fraser ME, Hayakawa K, Brown WD. Catalytic Role of the Conformational Change in Succinyl-CoA:3-Oxoacid CoA Transferase on Binding CoA. Biochemistry. 2010 Oct 26. PMID:20977214 doi:10.1021/bi100659s
