Sandbox Reserved 695

This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.

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Epileptic drugs at Voltage-Gated Sodium Ion Channel

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Introduction

STILL MAKING FINAL ADDITIONS

Under normal circumstances, the voltage gated sodium channel, or (VGSC), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms . However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials

Structure

The structure of the VGSC has four homologhous domains in vivo, however, for better illustration of the structures at work, the structure shown will only contain one subunit. The secondary structure includes alpha helices (blue) and beta strands (red).

References

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Alpha Helices and Beta Sheets

Ligand Binding Ligand binding Space-fill

____/5 Background info ____/5 Structural elements ____Structure ____Description ____/5 Interactions ____Structure ____Description ____/5 Active site ____Structure ____Description ____/5 Mechanism ____Structure ____Description ____/5 Inhibitors ____Structure ____Description ____/5 Interactions/ effectors ___Structure ____Description ____ additional cool stuff. ____Structure ____Description