3pr2 | pdb_00003pr2
From Proteopedia
Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site
Function
[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
About this Structure
3pr2 is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
See Also
Reference
- Lai J, Niks D, Wang Y, Domratcheva T, Barends TR, Schwarz F, Olsen RA, Elliott DW, Fatmi MQ, Chang CE, Schlichting I, Dunn MF, Mueller LJ. X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase. J Am Chem Soc. 2011 Jan 12;133(1):4-7. Epub 2010 Dec 10. PMID:21142052 doi:10.1021/ja106555c
