3q0h | pdb_00003q0h
From Proteopedia
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)
Function
[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
About this Structure
3q0h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
