3znp | pdb_00003znp
From Proteopedia
IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
Function
[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]
About this Structure
3znp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- D-amino-acid oxidase
- Homo sapiens
- Allen, M S.
- Bowen, C A.
- Chytil, M.
- Fang, Q K.
- Foglesong, R J.
- Hardy, L W.
- Heffernan, M L.R.
- Hopkins, S C.
- Jones, S W.
- Koch, P.
- Large, T H.
- Melnick, L.
- Molla, G.
- Nardini, M.
- Oliet, S H.R.
- Orsini, M A.
- Panatier, A.
- Piubelli, L.
- Pollegioni, L.
- Saraswat, L D.
- Soukri, M.
- Spear, K L.
- Varney, M A.
- Neurotransmission
- Oxidoreductase
- Small molecule inhibition
