3vtm | pdb_00003vtm
From Proteopedia
Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin
Template:ABSTRACT PUBMED 21797259
Function
[ISDH_STAAM] Binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone (By similarity).
About this Structure
3vtm is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus mu50. Full crystallographic information is available from OCA.
Reference
- Moriwaki Y, Caaveiro JM, Tanaka Y, Tsutsumi H, Hamachi I, Tsumoto K. Molecular basis of recognition of antibacterial porphyrins by heme-transporter IsdH-NEAT3 of Staphylococcus aureus. Biochemistry. 2011 Aug 30;50(34):7311-20. Epub 2011 Aug 4. PMID:21797259 doi:10.1021/bi200493h
- Watanabe M, Tanaka Y, Suenaga A, Kuroda M, Yao M, Watanabe N, Arisaka F, Ohta T, Tanaka I, Tsumoto K. Structural basis for multimeric heme complexation through a specific protein-heme interaction: the case of the third neat domain of IsdH from Staphylococcus aureus. J Biol Chem. 2008 Oct 17;283(42):28649-59. Epub 2008 Jul 30. PMID:18667422 doi:10.1074/jbc.M803383200
