4f3c | pdb_00004f3c
From Proteopedia
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with butyl-thio-DADMe-Immucillin-A
Function
[E8NLP5_SALET] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity).[HAMAP-Rule:MF_01684]
About this Structure
4f3c is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50. Full crystallographic information is available from OCA.
Reference
- Haapalainen AM, Thomas K, Tyler PC, Evans GB, Almo SC, Schramm VL. Salmonella enterica MTAN at 1.36 A Resolution: A Structure-Based Design of Tailored Transition State Analogs. Structure. 2013 May 14. pii: S0969-2126(13)00121-4. doi:, 10.1016/j.str.2013.04.009. PMID:23685211 doi:10.1016/j.str.2013.04.009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Adenosylhomocysteine nucleosidase
- Salmonella enterica subsp. enterica serovar choleraesuis str. scsa50
- Almo, S C.
- Bonanno, J B.
- Haapalainen, A M.
- Schramm, V L.
- Thomas, K.
- 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase
- Acting on glycosyl bond
- Adenosylhomocysteine nucleosidase activity
- Hydrolase-hydrolase inhibitor complex
- L-methionine biosynthetic process from s-adenosylmethionine
- L-methionine salvage from methylthioadenosine
- Methylthioadenosine nucleosidase activity
