4hr9 | pdb_00004hr9

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Template:STRUCTURE 4hr9

Human interleukin 17A

Template:ABSTRACT PUBMED 23695682

Function

[IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

About this Structure

4hr9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Liu S, Song X, Chrunyk BA, Shanker S, Hoth LR, Marr ES, Griffor MC. Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nat Commun. 2013;4:1888. doi: 10.1038/ncomms2880. PMID:23695682 doi:10.1038/ncomms2880

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OCA

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