2gx9 | pdb_00002gx9
X-ray strucutre of influenza virus NS1 effector domain
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Overview
The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains.
About this Structure
2GX9 is a Single protein structure of sequence from Unidentified influenza virus with SCN as ligand. Full crystallographic information is available from OCA.
Reference
X-ray structure of influenza virus NS1 effector domain., Bornholdt ZA, Prasad BV, Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21. PMID:16715094
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