3rz2 | pdb_00003rz2
From Proteopedia
Crystal of Prl-1 complexed with peptide
Function
[TP4A1_RAT] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
About this Structure
3rz2 is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY. PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. J Biol Chem. 2011 Dec 9;286(49):42316-24. Epub 2011 Oct 18. PMID:22009749 doi:10.1074/jbc.M111.286302
