4gfk | pdb_00004gfk
From Proteopedia
structures of NO factors
Function
[SLMA_VIBCH] Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity).
About this Structure
4gfk is a 2 chain structure with sequence from Vibrio cholerae o1 biovar el tor str. n16961. Full crystallographic information is available from OCA.
Reference
- Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA. SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. Proc Natl Acad Sci U S A. 2013 Jun 10. PMID:23754405 doi:10.1073/pnas.1221036110
