4bq8 | pdb_00004bq8
From Proteopedia
Crystal structure of the RGMB-NEO1 complex form 3
Function
[NEO1_MOUSE] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [RGMB_HUMAN] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
About this Structure
4bq8 is a 3 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
- Bell CH, Healey E, van Erp S, Bishop B, Tang C, Gilbert RJ, Aricescu AR, Pasterkamp RJ, Siebold C. Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub. Science. 2013 Jun 6. PMID:23744777 doi:10.1126/science.1232322
