4hj0 | pdb_00004hj0

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Template:STRUCTURE 4hj0

Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution

Template:ABSTRACT PUBMED 23689510

Function

[GIPR_HUMAN] This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

About this Structure

4hj0 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Ravn P, Madhurantakam C, Kunze S, Matthews E, Priest C, O'brien S, Collinson A, Papworth M, Fritsch-Fredin M, Jermutus L, Benthem L, Gruetter M, Jackson RH. Structural and Pharmacological Characterisation of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-Dependent Insulinotropic Polypeptide Receptor. J Biol Chem. 2013 May 20. PMID:23689510 doi:10.1074/jbc.M112.426288

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OCA

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