4axm | pdb_00004axm

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Template:STRUCTURE 4axm

TRIAZINE CATHEPSIN INHIBITOR COMPLEX

Template:ABSTRACT PUBMED 23658062

Function

[CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.

About this Structure

4axm is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Ehmke V, Winkler E, Banner DW, Haap W, Schweizer WB, Rottmann M, Kaiser M, Freymond C, Schirmeister T, Diederich F. Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L. ChemMedChem. 2013 Jun;8(6):967-75. doi: 10.1002/cmdc.201300112. Epub 2013 May 9. PMID:23658062 doi:10.1002/cmdc.201300112

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OCA

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