4ixf | pdb_00004ixf
From Proteopedia
pcDHFR-269 F69N variant
Function
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
4ixf is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.
Reference
- Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g
