3zpr | pdb_00003zpr
From Proteopedia
Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound
Template:ABSTRACT PUBMED 23517028
Function
[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
About this Structure
3zpr is a 2 chain structure with sequence from Meleagris gallopavo. Full crystallographic information is available from OCA.
Reference
- Christopher J, Brown J, Dore A, Errey J, Koglin M, Marshall FH, Myszka D, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. Biophysical fragment screening of the beta1-adrenergic receptor: Identification of high affinity aryl piperazine leads using structure-based drug design. J Med Chem. 2013 Mar 21. PMID:23517028 doi:10.1021/jm400140q
