4kk2 | pdb_00004kk2
From Proteopedia
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
Function
[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]
About this Structure
4kk2 is a 2 chain structure with sequence from Artemisia spiciformis. Full crystallographic information is available from OCA.
Reference
- ↑ Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Artemisia spiciformis
- Almo, S C.
- Bhosle, R.
- Chowdhury, S.
- Evans, B.
- Gerlt, J A.
- Glenn, A Scott.
- Hammonds, J.
- Hillerich, B.
- Imker, H J.
- Initiative, Enzyme Function.
- Love, J.
- Obaidi, N F.Al.
- Poulter, C D.
- Seidel, R D.
- Toro, R.
- Vetting, M W.
- Washington, E.
- Enzyme function initiative
- Isoprenoid synthase
- Structural genomic
- Transferase
