4fx9 | pdb_00004fx9

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Template:STRUCTURE 4fx9

Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase

Template:ABSTRACT PUBMED 23530771

Function

[CDR_PYRHO] Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo.

About this Structure

4fx9 is a 2 chain structure with sequence from Pyrococcus horikoshii ot3. Full crystallographic information is available from OCA.

Reference

  1. Herwald S, Liu AY, Zhu BE, Sea KW, Lopez KM, Sazinsky MH, Crane Iii EJ. Characterization of the structure and substrate specificity of the pyrococcal CoADR/Psr: Implications for S0-based respiration and a sulfur-dependent antioxidant system in Pyrococcus. Biochemistry. 2013 Mar 26. PMID:23530771 doi:10.1021/bi3014399

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