3bsu | pdb_00003bsu

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Template:STRUCTURE 3bsu

Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA

Template:ABSTRACT PUBMED 18337749

Function

[RNH1_HUMAN] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

About this Structure

3bsu is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. EMBO J. 2008 Apr 9;27(7):1172-81. Epub 2008 Mar 13. PMID:18337749 doi:10.1038/emboj.2008.44

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