4kfn | pdb_00004kfn
From Proteopedia
Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Template:ABSTRACT PUBMED 23617784
Function
[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
About this Structure
4kfn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, Oh A, Wang W, Zak M, Gunzner-Toste J, Zhao G, Yuen PW, Bair KW. Structure-based Identification of Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors. J Med Chem. 2013 Apr 25. PMID:23617784 doi:10.1021/jm400186h
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Nicotinamide phosphoribosyltransferase
- Bair, K W.
- Bauer, P.
- Baumeister, T.
- Brien, T O.
- Buckmelter, A J.
- Caligiuri, M.
- Clodfelter, K H.
- Dragovich, P S.
- Gunzner-Toste, J.
- Han, B.
- Ho, Y.
- Kley, N.
- Liederer, B M.
- Lin, J.
- Ly, J.
- Oh, A.
- Reynolds, D J.
- Sharma, G.
- Smith, C C.
- Wang, L.
- Wang, W.
- Wang, Z.
- Xiao, Y.
- Yuen, P.
- Zak, M.
- Zhao, G.
- Zheng, X.
- Transferase-transferase inhibitor complex
