3qg2 | pdb_00003qg2

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Template:STRUCTURE 3qg2

Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex

Template:ABSTRACT PUBMED 21650210

Function

[D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

3qg2 is a 2 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

  1. Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y. Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance. ACS Chem Biol. 2011 Jun 16. PMID:21650210 doi:10.1021/cb200124r

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OCA

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