4g35 | pdb_00004g35
From Proteopedia
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
Function
[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
About this Structure
4g35 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q. Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J Am Chem Soc. 2012 Sep 12;134(36):14734-7. doi: 10.1021/ja306864v. Epub 2012 Sep, 4. PMID:22920569 doi:10.1021/ja306864v
