3w1f | pdb_00003w1f
From Proteopedia
Crystal structure of Human MPS1 catalytic domain in complex with 5-(5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)-2-methylbenzenesulfonamide
Function
[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]
About this Structure
3w1f is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kusakabe K, Ide N, Daigo Y, Tachibana Y, Itoh T, Yamamoto T, Hashizume H, Hato Y, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Yasuo K, Maeda M, Higaki M, Ueda K, Yoshizawa H, Baba Y, Shiota T, Murai H, Nakamura Y. Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). J Med Chem. 2013 Jun 13;56(11):4343-56. doi: 10.1021/jm4000215. Epub 2013 May 24. PMID:23634759 doi:10.1021/jm4000215
- ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Dual-specificity kinase
- Homo sapiens
- Baba, Y.
- Daigo, Y.
- Dohi, K.
- Hashizume, H.
- Hato, Y.
- Higaki, M.
- Higashino, K.
- Ide, N.
- Iguchi, M.
- Inoue, M.
- Ishioka, Y.
- Itoh, T.
- Kanazawa, T.
- Kido, Y.
- Kusakabe, K.
- Maeda, M.
- Murai, H.
- Nakamura, Y.
- Okano, Y.
- Sakamoto, S.
- Sato, Y.
- Shiota, T.
- Tachibana, Y.
- Ueda, K.
- Yamamoto, T.
- Yasuo, K.
- Yoshizawa, H.
- Kinase
- Serine/threonine-protein kinase
- Transferase-transferase inhibitor complex
