Mur ligase

<StructureSection load='2jfg' size='350' side='right' caption='Structure of MurD ligase complex with UMA, ADP and sulfate (PDB entry 2jfg)' scene=>

MurD ligase or UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase catalyzes the conversion of UDP-N-acetylmuramoyl-L-alanine (UMA), D-glutamate and ATP to UDP-N-acetylmuramoyl-L-alanine-D-glutamate and ADP. MurD is part of the bacterial peptidoglycan synthesis pathway.

3D Structures of MurD ligase

Updated on 03-July-2013

1e0d – EcMurD – Escherichia coli
3lk7 – MurD – Streptococcus agalactiae

MurD complex with ligand

1uag, 1eeh – EcMurD + UMA
2jfg – EcMurD + UMA + ADP
2uag – EcMurD + UMA + ADP + Mg
3uag – EcMurD + UMA + ADP + Mn
4uag – EcMurD + UAG

MurD complex with inhibitor

2jff, 2jfh, 2uuo, 2uup, 2vtd, 2vte, 2xpc – EcMurD + sulfonamide inhibitor
2wjp – EcMurD + rhodanine inhibitor
2x5o, 2y68, 2y66, 2y67, 2y1o – EcMurD + thiazolidine inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman