4bhp | pdb_00004bhp

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Template:STRUCTURE 4bhp

A structural model of CAP mutant (T127L and S128I) in cGMP-bound state

Template:ABSTRACT PUBMED 23644478

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4bhp is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

  1. Tzeng SR, Kalodimos CG. Allosteric inhibition through suppression of transient conformational states. Nat Chem Biol. 2013 May 5. doi: 10.1038/nchembio.1250. PMID:23644478 doi:10.1038/nchembio.1250
  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

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