3syv | pdb_00003syv
From Proteopedia
Crystal structure of mPACSIN 3 F-BAR domain mutant
Function
[PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
About this Structure
3syv is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Bai X, Meng G, Luo M, Zheng X. The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules. J Biol Chem. 2012 May 9. PMID:22573331 doi:10.1074/jbc.M112.358960
