1yb1 | pdb_00001yb1
From Proteopedia
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Function
[DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
About this Structure
1yb1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- 17-beta-estradiol 17-dehydrogenase
- Homo sapiens
- Arrowsmith, C.
- Bray, J.
- Bunkoczi, G.
- Delft, F Von.
- Edwards, A.
- Kavanagh, K.
- Lukacik, P.
- Ng, S.
- Oppermann, U.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Human
- Hydroxysteroid dehydrogenase
- Oxidoreductase
- Sgc
- Short chain dehydrogenase
- Structural genomic
- Structural genomics consortium
