4bkx | pdb_00004bkx
From Proteopedia
The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
Function
[MTA1_HUMAN] May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
About this Structure
4bkx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW. Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol Cell. 2013 Jun 19. pii: S1097-2765(13)00407-3. doi:, 10.1016/j.molcel.2013.05.020. PMID:23791785 doi:10.1016/j.molcel.2013.05.020
