2m10 | pdb_00002m10

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Template:STRUCTURE 2m10

trans form of a photoswitchable PDZ domain crosslinked with an azobenzene derivative

Template:ABSTRACT PUBMED 23818626

Function

[PTN13_HUMAN] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.[1]

About this Structure

2m10 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. Buchli B, Waldauer SA, Walser R, Donten ML, Pfister R, Blochliger N, Steiner S, Caflisch A, Zerbe O, Hamm P. Kinetic response of a photoperturbed allosteric protein. Proc Natl Acad Sci U S A. 2013 Jul 1. PMID:23818626 doi:10.1073/pnas.1306323110
  1. ↑ Villa F, Deak M, Bloomberg GB, Alessi DR, van Aalten DM. Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket. J Biol Chem. 2005 Mar 4;280(9):8180-7. Epub 2004 Dec 20. PMID:15611135 doi:10.1074/jbc.M412211200

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