3u4i | pdb_00003u4i

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Template:STRUCTURE 3u4i

CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template

Template:ABSTRACT PUBMED 23840430

Function

[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

About this Structure

3u4i is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Moreau C, Liu Q, Graeff R, Wagner GK, Thomas MP, Swarbrick JM, Shuto S, Lee HC, Hao Q, Potter BV. CD38 Structure-Based Inhibitor Design Using the 1-Cyclic Inosine 5'-Diphosphate Ribose Template. PLoS One. 2013 Jun 19;8(6):e66247. Print 2013. PMID:23840430 doi:10.1371/journal.pone.0066247

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OCA

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