3bnz | pdb_00003bnz

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Template:STRUCTURE 3bnz

Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor

Template:ABSTRACT PUBMED 21696158

Function

[TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.

About this Structure

3bnz is a 1 chain structure with sequence from Lactobacillus casei. Full crystallographic information is available from OCA.

See Also

Reference

  1. Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67. Epub 2011 Jul 12. PMID:21696158 doi:10.1021/jm2005018

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OCA

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