4k6l | pdb_00004k6l

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Template:STRUCTURE 4k6l

Structure of Typhoid Toxin

Template:ABSTRACT PUBMED 23842500

Function

[CDTB_SALTI] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.

About this Structure

4k6l is a 7 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhi. Full crystallographic information is available from OCA.

Reference

  1. Song J, Gao X, Galan JE. Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500 doi:10.1038/nature12377

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OCA

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