2yjz | pdb_00002yjz
From Proteopedia
Rat STEAP4 oxidoreductase domain complexed with NADP
Function
[STEA4_RAT] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
About this Structure
2yjz is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM. The Crystal Structure of Six-transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-binding Site. J Biol Chem. 2013 Jul 12;288(28):20668-82. doi: 10.1074/jbc.M113.479154. Epub, 2013 Jun 3. PMID:23733181 doi:10.1074/jbc.M113.479154
