4ksd | pdb_00004ksd

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Template:STRUCTURE 4ksd

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

About this Structure

4ksd is a 2 chain structure with sequence from Lama glama and Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

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OCA

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