4j8e | pdb_00004j8e
From Proteopedia
Middle domain of Hsc70-interacting protein, crystal form I
Template:ABSTRACT PUBMED 23812373
Function
[F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
About this Structure
4j8e is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Li Z, Hartl FU, Bracher A. Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Nat Struct Mol Biol. 2013 Aug;20(8):929-35. doi: 10.1038/nsmb.2608. Epub 2013 Jun, 30. PMID:23812373 doi:10.1038/nsmb.2608
