3gmd | pdb_00003gmd

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Template:STRUCTURE 3gmd

Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I

Template:ABSTRACT PUBMED 22901389

Function

[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

About this Structure

3gmd is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi:, 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. PMID:22901389 doi:10.1016/j.bmcl.2012.07.070

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