2loc | pdb_00002loc

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Template:STRUCTURE 2loc

Conotoxin analogue [D-Ala2]BuIIIB

Template:ABSTRACT PUBMED 23557677

Function

[CM3B_CONBU] Mu-conotoxins block voltage-gated sodium channels. Extremely potent inhibitor of Nav1.4/SCN4A. The inhibition is very slowly reversible.

About this Structure

2loc is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Mammalian Neuronal Sodium Channel Blocker mu-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency. ACS Chem Biol. 2013 Apr 16. PMID:23557677 doi:10.1021/cb300674x

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OCA

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