2z5i | pdb_00002z5i
Crystal structure of the head-to-tail junction of tropomyosin
Template:ABSTRACT PUBMED 18483193
Function
[GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'. [TPM1_RABIT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
About this Structure
2z5i is a 10 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
See Also
Reference
- Murakami K, Stewart M, Nozawa K, Tomii K, Kudou N, Igarashi N, Shirakihara Y, Wakatsuki S, Yasunaga T, Wakabayashi T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7200-5. Epub 2008 May 15. PMID:18483193 doi:10.1073/pnas.0801950105
