3l9k | pdb_00003l9k

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Template:STRUCTURE 3l9k

Insights into dynein assembly from a dynein intermediate chain-light chain roadblock structure

Function

[DYIN_DROME] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).[1]

About this Structure

3l9k is a 8 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hall J, Song Y, Karplus PA, Barbar E. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. J Biol Chem. 2010 Jul 16;285(29):22566-75. Epub 2010 May 15. PMID:20472935 doi:10.1074/jbc.M110.103861
  1. ↑ Boylan K, Serr M, Hays T. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Mol Biol Cell. 2000 Nov;11(11):3791-803. PMID:11071907

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OCA

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