4ht6 | pdb_00004ht6
The Structure of a Yeast Dynein Dyn2-Pac11 Complex and Effect on Single Molecule Dynein Motor Activity
Template:ABSTRACT PUBMED 23761070
Function
[DYL1_YEAST] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). [PAC11_YEAST] Required for viability in the absence of the kinesin-related CIN8 mitotic motor. May be a dynein intermediate chain.
About this Structure
4ht6 is a 6 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
Reference
- Rao L, Romes EM, Nicholas MP, Brenner S, Tripathy A, Gennerich A, Slep KC. The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization. Mol Biol Cell. 2013 Aug;24(15):2362-2377. Epub 2013 Jun 12. PMID:23761070 doi:10.1091/mbc.E13-03-0166
