4l00 | pdb_00004l00
From Proteopedia
Crystal structure of the apo Jak1 pseudokinase domain
Template:ABSTRACT PUBMED 24013208
Function
[JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
About this Structure
4l00 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Sep 8. doi: 10.1038/nsmb.2673. PMID:24013208 doi:10.1038/nsmb.2673
