3a5y | pdb_00003a5y
From Proteopedia
Crystal structure of GenX from Escherichia coli in complex with lysyladenylate analog
Function
[C3SGA2_ECOLX] With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34' (By similarity).[HAMAP-Rule:MF_00174]
About this Structure
3a5y is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Yanagisawa T, Sumida T, Ishii R, Takemoto C, Yokoyama S. A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat Struct Mol Biol. 2010 Sep;17(9):1136-43. Epub 2010 Aug 22. PMID:20729861 doi:10.1038/nsmb.1889
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Escherichia coli
- Lysine--tRNA ligase
- Ishii, R.
- Sumida, T.
- Yanagisawa, T.
- Yokoyama, S.
- Aminoacyl-trna synthetase
- Aminoacyl-trna synthetase paralog
- Ligase
- Lysyl-trna synthetase
- Lysyladenylate analog
- National project on protein structural and functional analyse
- Nppsfa
- Riken structural genomics/proteomics initiative
- Rsgi
- Structural genomic
- Translation
- Trna
