4j4q | pdb_00004j4q
From Proteopedia
Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
Function
[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
About this Structure
4j4q is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP. Opsin, a structural model for olfactory receptors? Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729 doi:https://dx.doi.org/10.1002/anie.201302374
- ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
- ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Bos taurus
- Choe, H W.
- Ernst, O P.
- Hofmann, K P.
- Hong, J E.
- Li, Y.
- Morizumi, T.
- Pai, E F.
- Park, J H.
- G-protein coupled receptor
- Galpha subunit
- Glycoprotein
- Gtp-binding
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Photoreceptor protein
- Receptor retinal protein
- Retinal binding
- Sensory transduction
- Signaling protein
- Transducer
- Transmembrane
