1p9l | pdb_00001p9l
From Proteopedia
Structure of M. tuberculosis dihydrodipicolinate reductase in complex with NADH and 2,6 PDC
Function
[DAPB_MYCTU] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.[1]
About this Structure
1p9l is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:https://dx.doi.org/10.1021/bi030044v
- ↑ Cirilli M, Zheng R, Scapin G, Blanchard JS. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry. 2003 Sep 16;42(36):10644-50. PMID:12962488 doi:https://dx.doi.org/10.1021/bi030044v
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- 4-hydroxy-tetrahydrodipicolinate reductase
- Mycobacterium tuberculosis
- Blanchard, J S.
- Cirilli, M.
- Scapin, G.
- TBSGC, TB Structural Genomics Consortium.
- Zheng, R.
- Lysine biosynthesis
- Nadh binding specificity
- Oxidoreductase
- Protein structure initiative
- Psi
- Reductase
- Structural genomic
- Tb structural genomics consortium
- Tbsgc
