3d4y | pdb_00003d4y

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Template:STRUCTURE 3d4y

GOLGI MANNOSIDASE II complex with mannoimidazole

Template:ABSTRACT PUBMED 18759458

Function

[MAN2_DROME] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).

About this Structure

3d4y is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

See Also

Reference

  1. Kuntz DA, Tarling CA, Withers SG, Rose DR. Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Biochemistry. 2008 Sep 23;47(38):10058-68. Epub 2008 Aug 30. PMID:18759458 doi:10.1021/bi8010785

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