4cbf | pdb_00004cbf
From Proteopedia
Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus
Template:ABSTRACT PUBMED 24155405
Function
[E0WXI2_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774]
About this Structure
4cbf is a 6 chain structure with sequence from Dengue virus 2 and Dengue virus 4. Full crystallographic information is available from OCA.
Reference
- Kostyuchenko VA, Chew PL, Ng TS, Lok SM. Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus. J Virol. 2013 Oct 23. PMID:24155405 doi:https://dx.doi.org/10.1128/JVI.02641-13
