4cct | pdb_00004cct

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Revision as of 07:39, 6 November 2013 by OCA (talk | contribs) (New page: {{STRUCTURE_4cct| PDB=4cct | SCENE= }} ===Dengue 1 cryo-EM reconstruction=== {{ABSTRACT_PUBMED_23637416}} ==Function== http://www.uniprot.org/uniprot/G3F5K5_9FLAV G3F5K5_9FLAV En...)
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Template:STRUCTURE 4cct

Dengue 1 cryo-EM reconstruction

Template:ABSTRACT PUBMED 23637416

Function

[G3F5K5_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

About this Structure

4cct is a 6 chain structure with sequence from Dengue virus 1. Full crystallographic information is available from OCA.

Reference

  1. Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM. Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. J Virol. 2013 Jul;87(13):7700-7. doi: 10.1128/JVI.00197-13. Epub 2013 May 1. PMID:23637416 doi:10.1128/JVI.00197-13

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