4lrr | pdb_00004lrr

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Template:STRUCTURE 4lrr

Ternary complex between E. coli thymidylate synthase, dUMP, and F9

Template:ABSTRACT PUBMED 24147825

Function

[TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

About this Structure

4lrr is a 1 chain structure with sequence from Escherichia coli o157:h7. Full crystallographic information is available from OCA.

Reference

  1. Ferrari S, Calo S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. 2'-deoxyuridine-5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem. 2013 Oct 22. PMID:24147825 doi:https://dx.doi.org/10.1021/jm4014086

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OCA

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