3g60 | pdb_00003g60

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Template:STRUCTURE 3g60

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Template:ABSTRACT PUBMED 19325113

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

About this Structure

3g60 is a 2 chain structure with sequence from Lk3 transgenic mice. The March 2010 RCSB PDB Molecule of the Month feature on P-glycoprotein by David Goodsell is 10.2210/rcsb_pdb/mom_2010_3. Full crystallographic information is available from OCA.

Reference

  1. Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718
  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

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